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The drug Trenbolone is, without a doubt, the most powerful injectable anabolic steroid used by Steroid.com members to gain muscle. However the full properties of the drug are not always fully understood. This profile will separate fact from fiction and help steroid.com members decide if Trenbolone is right for them.
Trenbolone is similar to the highly popular steroid Nandrolone, in that they are both 19-nor steroids, meaning that a testosterone molecule has been altered at the 19th position to give us a new compound. Unlike Nandrolone however Trenbolone is an excellent mass and hardening drug with the majority of gains being muscle fiber, with minimal water retention (1) It has an unbelievable anabolic (muscle building) score of 500. When you compare that to Testosterone, which itself is a powerful mass builder, and has an anabolic score of 100 you can begin to fathom the muscle building potential of Trenbolone. What makes Trenbolone so anabolic? Numerous factors come into play. Trenbolone greatly increases the level of the extremely anabolic hormone IGF-1 within muscle tissue (2). And, its worth noting that not only does it increase the levels of IGF-1 in muscle over two fold, it also causes muscle satellite cells (cells that repair damaged muscle) to be more sensitive to IGF-1 and other growth factors(3). The amount of DNA per muscle cell may also be significantly increased (3).
Trenbolone also has a very strong binding affinity to the androgen receptor (A.R), binding much more strongly than testosterone (4). This is important, because the stronger a steroid binds to the androgen receptor the better that steroid works at activating A.R dependent mechanisms of muscle growth. There is also strong supporting evidence that compounds which bind very tightly to the androgen receptor also aid in fat loss. Think as the receptors as locks and androgen’s as different keys, with some keys (androgen’s) opening (binding) the locks (receptors) much better than others. This is not to say that AR-binding is the final word on a steroids effectiveness. Anadrol doesnt have any measurable binding to the AR& and we all know how potent Anadrol is for mass-building.
Trenbolone increases nitrogen retention in muscle tissue (5). This is of note because nitrogen retention is a strong indicator of how anabolic a substance is. However, it’s incredible mass building effects do not end there. Trenbolone has the ability to bind with the receptors of the anti-anabolic (muscle destroying) glucocorticoid hormones (6). This may also has the effect of inhibiting the catabolic (muscle destroying) hormone cortisol (7).
Yet another amazing trait that must be noted is its ability to improve feed efficiency and mineral absorption in animals given the drug (8). To help you understand what this means for you, feed efficiency is a measurement of how much of an animals diet is converted into meat, and the more food it takes to produce this meat, the lower the efficiency. Conversely, the less food it takes to produce meat the, higher the efficiency& well you get the idea. Animals given Trenbolone gained high quality weight without having their diet adjusted, thus improving feed efficiency. Finding new compounds which can improve feed efficiency is a billion dollar industry, and has spawned many nutritional advances in the bodybuilding world over the last few decades (CLA, Whey Protein, and HMB are compounds which spring to mind as having first been introduced by the livestock industry). What does this translate to for the hard training athlete? The food you eat will be better utilized for building lean muscle, and vitamins and minerals are also better absorbed which may keep you healthier during cycle.
Winstrol is one of the most popular and well-known anabolic steroids on earth. Developed by Winthrop Laboratories in the late 1950’s, this is an anabolic steroid that has gotten a lot of media attention over the years. In fact, those who have never used anabolic steroids, if they can name a steroid it’s usually Winstrol or Stanozolol. The name Winstrol is actually the most commonly associated brand name of the Stanozolol hormone. This is an anabolic steroid that has garnered worldwide attention due to numerous athletic scandals over the years. When various athletes have been caught using anabolic steroids, Winstrol has been at the forefront of the scandal countless times. In fact, it is associated with the most important athletic steroid scandal in history.
In 1988, Canadian sprinter Ben Johnson tested positive for the steroid after taking the gold at that year’s Summer Olympics. Not only did Johnson destroy his competition, he handedly defeated the highly favored Carl Lewis with relative ease. This would lead to Stanozolol making countless news headlines for a very long time and more importantly truly usher in the U.S. government’s war on steroids. The Johnson scenario is not the largest athletic based steroid scandal to ever occur, which would probably belong to the decades long East German doping machine; however, the Johnson scandal would have the largest impact. When Ben Johnson destroyed the U.S. golden boy, many point to this as being the final nail in the coffin that the U.S. congress needed to justify classifying anabolic steroids as Schedule III controlled substances.
While one of the more well-known anabolic steroids, Winstrol is very popular among most in the steroid using population. It is in many ways a fairly mild anabolic steroid that can be safely used by men and women. Equally important, it has proven highly effective for numerous performance enhancement endeavors. It is a long standing favorite among competitive bodybuilders and physique based athletes during cutting or contest prep phases. It is also a top steroid of choice for numerous performance athletes due to its ability to promote strength and endurance without unwanted mass.
Beyond performance enhancement, Winstrol has had a lot of success in modern medicine. It has been successfully used to combat lean tissue wasting and has had a lot of success in preserving bone mass in cases of osteoporosis. Winstrol has also been used to combat prolonged exposure to corticosteroid treatment, given to burn victims and even used to aid in the healing of severe bone fractures. The steroid has also enjoyed a little success in treating obesity when hormonal assistance is needed, as well as treating delayed growth in some children. As the years have passed, Winstrol has remained available for treatment for most of these conditions as well as being proven highly successful in treating angioedema among a few other treatment plans such as specific forms of breast cancer. The steroid has never lost FDA approval and unlike many anabolic steroids has maintained approval for numerous therapeutic treatment plans.
Stanozolol is a dihydrotestosterone (DHT) derived anabolic androgenic steroid, or more specifically a structurally altered form. Stanozolol is the DHT hormone with two structural changes that give us the Winstrol compound. The first alteration is the introduction of an attached pyrazol group at the A-ring of the hormone replacing the 3-keto group. This modification officially classifies Stanozolol as a heterocyclic steroid. The hormone also carries an added methyl group in order to protect hormone after administration. This structural change takes place at the 17th carbon position officially classifying Stanozolol as a C17-alpha alkylated (C17-aa) anabolic steroid.
Due the combination of structural changes, this reduces the hormone’s androgenicity significantly and greatly increases its anabolic power. Officially Winstrol carries an anabolic rating of 320 and an androgenic rating of 20. More importantly, its ratings translate perfectly in real life effects giving us an extremely beneficial anabolic steroid.
Winstrol carries many positive steroidal traits, one of which is its ability to lower Sex-Hormone-Binding-Globulin (SHBG) significantly. This allows for more of the steroids being supplied to rest in an unbound state, as well as provides an increase in free testosterone. While many anabolic steroids lower SHBG Winstrol appears to have a much stronger affinity than most. In fact, studies have demonstrated nearly 50% reductions in SHBG in mere days of use and even at relatively low doses.
Beyond a reduction in SHBG, which is one of its primary traits, Winstrol will enhance protein synthesis and greatly increase nitrogen retention in the muscles. The steroid will also do a fairly decent job at increasing red blood cell count and inhibiting glucocorticoid hormones but not to the degree of many other steroids. In many ways, we have a mild yet evenly possession of some basic steroidal traits coupled with the dramatic SHBG reduction that gives us a controllable and unique compound. This really is one of the easiest anabolic steroids to understand.
When looking at the direct functions and traits of Winstrol there is one more issue we need to discuss. The Stanozolol hormone is both an injectable an oral anabolic steroid. Both forms are comprised of the same identical Stanozolol hormone. 1mg of one form is the same as 1mg of the other form. Some studies have suggested oral Winstrol may reduce SHBG a little more than its injectable counterpart, while others have said injectable forms may be slightly more potent on an overall milligram for milligram basis. However, overall these appear to be rather insignificant differences regardless of the direction they go. In fact, the individual should be able to receive the same identical benefits with either form.
Another important note often misunderstood about Winstrol forms is the C17-aa nature. Both oral and injectable Stanozolol are C17-aa anabolic steroids. Most oral steroids are C17-aa and while injectable steroids rarely are injectable Stanozolol is one of the exceptions. The injectable form is also commonly referred to as Winstrol Depot.
Although used to stave off lean tissue wasting, Winstrol is not what we’d call a bulking steroid. You will rarely find this steroid in an off-season mass gaining stack. However, it could be used in an effort to enhance the activity of the other steroids being used due to the strong SHBG reduction it will provide but this is generally not recommended. When we dive into the side effects of Winstrol, we will find it is very hepatotoxic and use should be limited to when it’s most valuable. For the male athlete, this will not be during the bulking phase.
When it comes to off-season bulking, we could make more of an exception with female use. Females are far more sensitive to the steroid and short burst plans could be very beneficial during this phase. But again, there are probably better options.
The effects of Winstrol are undoubtedly most beneficial to direct performance enhancement of an athletic nature. We’re talking about functional competitive athletes, not bodybuilders or physique athletes. This steroid has the ability to greatly increase strength and this can translate into both power and speed. Further, it will accomplish this without adding a lot of additional weight that could hinder some depending on the sport, as well as cause unwanted attention from prying eyes. There have been those who have said Winstrol isn’t good for competitive athletes, especially those athletes in explosive sports due to potential weakening of the tendons but this is more or less message board anecdotal hysteria that supports this claim. In fact, many studies have shown it can have a positive impact on strengthening tendons and we already know it’s good for the bones. If not, it wouldn’t be used to treat osteoporosis.
There are also some who complain of joint pain when using Winstrol. As a steroid that does not aromatize there will be no water retention but the “dry feeling” may not be what many think it is. Most who use the steroid will be physique athletes or gym rats during a cutting phase. They will also typically add it into a plan late in the diet once they’re already lean. Typically, when you become very lean, bodybuilding lean, this makes the joints a little uncomfortable. With or without Winstrol this discomfort could potentially exist. As for pro athletes who have nearly every last steroid at their disposal, remember, if Winstrol weren’t effective in competitive sports so many athletes wouldn’t make it a primary and favorite choice. In fact, the combo of Winstrol with low doses of Nandrolone is a very common stack among many athletes, and this stack will greatly eliminate any potential joint discomfort should it exist.
Beyond athletics, the gym rat or bodybuilding effects of Winstrol will be best displayed once you’re already somewhat lean. The steroid will help produce a dryer, harder look but only if you’re relatively lean. It will also aid in lean tissue preservation but not to a very strong degree that’s often needed in such a phase. It’s typically recommended that Winstrol only be used in this capacity as a secondary steroid, not a base or foundational steroid.
Both men and women can greatly benefit from Winstrol during the cutting phase. While it won’t be the best lean tissue preserver, many report maintaining more of their strength that is often lost when dieting when Winstrol is in play. Vascularity should also become more pronounced and overall the individual should enjoy an overall enhancement in definition.
The side effects of Winstrol most certainly exist, but they largely fall into the category of possible rather than guaranteed. The side effects of Winstrol can be controlled but it will take some effort on your part. There is also always the issue of individual response. We all respond to different things differently. This not only holds true with various anabolic steroids but all things we put into our body. Most of use can take Aspirin, but there are others who will experience horrible side effects if they touch the first pill. Most of us can tolerate dairy products, but there are others who become very sick if they even look at a glass of milk. Individual response dictates quite a lot. With that in mind, in order to help you understand the possible side effects of Winstrol we have broken them down into their separate categories along with all you’ll need to know.
The first thing that you should know is that this anabolic steroid has a lot of the same properties as the compound, Nandrolone Decanoate (Deca). Actually, Nandrolone Phenylpropionate was marketed first, during the 50s. It was sold commercially under the brand name, Durabolin.
The company that made and sold Durabolin was called Organon. Later on, Organan would create a second formula, Nandrolone Decanoate, which was branded as Deca Durabolin.
This anabolic steroid has a small ester base and it’s known as NPP for short. It’s never achieved the same popularity as Decanoate, which has a large ester base. This is primarily because the Deconoate formula was easier to buy. It was sold in more places. However, these days, underground labs are producing Nandrolone Phenylpropionate and this is boosting its popularity. It’s being used more often because it’s easier to access.
It’s being made in underground labs because it’s isn’t legal in America and many other parts of the world. It’s actually tough to find NPP, although it’s easier than it used to be. This steroid is legal when it’s prescribed for a medical condition. However, most people who want it are looking for it because they want better results from bodybuilding. A doctor won’t prescribe it for this reason.
Why Use Nandrolone Phenylpropionate?
This anabolic steroid offers a host of performance benefits and therapeutic benefits. Aside from testosterone, the hormone known as Nandrolone is the anabolic steroid which is most-prescribed by doctors. However, the Decanoate formula is the most commonly-prescribed form of Nandrolone (rather than Nandrolone Phenylproprionate).
In general, people who use Nandrolone tolerate it very well. This isn’t to say that there is no risk of side effects. It’s an anabolic steroid and they all come with the risk of side effects.
Now, let’s look at the traits and function of this anabolic steroid. In terms of its scientific structure, it is an anabolic androgenic steroid of the 19-nortestosterone type. When the 19-nor classification applies, it means that a testosterone hormone structural change has taken place in the nineteenth position. The change is that the hormone’s carbon atom has been eliminated in position 19.
When this change is made to testosterone, Nandrolone is created. When a short ester called Phenylpropionate is added to the changed formula (which is Nandrolone), Nandrolone Phenylpropionate is created.
In terms of how Nandrolone Phenylpropionate functions, it’s just the same as Nandrolone Decanoate. Each one is made from the same hormone as the other. However, with NPP (Nandrolone Phenylpropionate), the half-life is shorter and the burst of Nandrolone is bigger, post-injection .
Basically, if you’re interested in keeping your blood levels stable, you’ll need to inject NPP more than you’ll need to inject Nandrolone Decanoate.
In terms of how NPP compares to testosterone, it’s more anabolic, but not by much. To put it into perspective, testosterone has a 125 rating, while testosterone has a rating of 100. It’s much less androgenic than testosterone, with a rating of 37. Testoesterone rates 100. Decreased androgenic properties are because Nandrolone reduces to DHN instead of reducing to DHT. For this reason, NPP is easier for males to tolerate in high doses, versus testosterone. DHN stands for dihydronandrolone and DHT stands for dihydrotestosterone.
In addition to being less androgenic, NPP is not as estogenic. NPP aromatizes testosterone eight percent less than testosterone does.
As well, you should know that Nandrolone Phenylpropionate has the nature, progestin, which impacts its side effects.
NPP has a lot of the good properties of other anabolics. However, it goes further by outpacing other steroids in terms of what it can do for the human body. To explain, we’d like to share information about the best traits of NPP.
If you want more production of IGF-1, which is “insulin-like growth factor), NPP will deliver. IGF-1 is a powerful hormone which is anabolic and it will assist the human body with recovering from training. This important hormone plays a role on a host of cells.
As well, NPP will inhibit Glucocorticoids. Glucocorticoids are cortisol stress hormones which play an important role in how we feel and in how healthy we are. However, it’s not a good thing when our levels of glucocorticoids are too high, as this may lead to fat gain and muscle loss. When we get a lot of physical exertion, we’re more likely to have higher level of stress hormones. The hormone, Nandrolone, is able to decrease stress hormone production.
Another advantage of NPP is that it will boost the retention of Nitrogen. Our tissue for muscle is made up of sixteen percent Nitrogen. When retention goes down, we enter a state which is catabolic. The more we keep, the more anabolic our bodies are.
Nandrolone Phenylpropionate will also increase the synthesis of protein. Protein synthesis is the pace at which cells will build proteins. Proteins are muscle tissue building blocks.
Also, Nandrolone will boost the our counts of red blood cells. These cells deliver oxygen to our bloodstreams. When red blood cell production rises, our muscular endurance increases and we recover with more ease.
Another positive aspect of NPP is that it will boost the synthesis of collagen and the content of bone minerals. If you want stronger cartilage and bones, as well as the capacity to recover from problems with bones and cartilage, then this anabolic steroid will likely be helpful. In particular, the enhanced collagen production and bone mineral production triggered by NPP will make good joint health easier to achieve.
NPP is also used in order to treat an array of medical conditions. Patients with HIV and cancer may benefit from injecting it, as may patients with fatigue and muscle-wasting illnesses. As well, those who are anemic may benefit. Other examples of conditions which may be treated with Nandrolone Phenylpropioniate include breast cancer, anemia, pituitary dwarfism, serious burns, ulcers, mental development problems (in children) and osteoporosis.
While it does offer benefits to a lot of different types of patients, in America, it’s typically prescribed to people who suffer from anemia, AIDS or HIV. It’s quite successful in terms of improving patient outcomes. In other parts of the world, it may be prescribed for other types of illnesses, in addition to the ones it’s used to treat in the USA. There are some incidences of it being used to slow down the aging process.
By now, we’ve reviews some of the main properties of this anabolic steroid. We know its key traits and functions. Now, we’d like to share information about how NPP helps performance athletes. Most people who are interested in NPP do fit this category!
In the off season, a performance athlete will typically enter a bulking cycle and NPP is an effective steroid for this phase. It’s designed to boost size and muscularity. If you want a mass builder which a lot of bodybuilders rely on, you’ll find that this one delivers. While it’s quite fast-acting, growth won’t be rapid. However, growth will occur in a steady manner.
Bear in mind that you’ll need to consume enough calories to grow effectively. This means eating more calories than you burn off. If you eat properly, you’ll get maximal benefits from NPP. Also, performance athletes may find that their bodies are leaner because this hormone speeds up their metabolisms. Also, recovery from training and injuries will be easier when you add Nandrolone Phenylpropionate to your bulking phase routine.
This hormone is also a popular choice for cutting cycles. However, it’s more renowned as a bulking steroid than a cutting one! When you use it for cutting, it will keep you from losing lean muscle mass. Unfortunately, when we begin to slim down during cutting phases, we run the risk of losing precious muscle tissue, as well as fat. This steroid will protect the muscle tissue that bodybuilders work so hard to keep.
If you want superb joint discomfort relief and recovery, NPP may be right for you. A lot of bodybuilders use it in smaller doses in order to access this benefit. The steroid doesn’t mask symptoms. Instead, it provides real relief. Strength gains may also happen with this steroid. However, it’s not usually chosen for this reason.
Now, let’s talk about the downside. With steroids, there is always a downside. As we mentioned earlier, this steroid is one that most people tolerate well. However, you need to know the risks…
This steroid does cause side effects in some users. However, it’s definitely not one of the steroids which is known for its nasty side effects. If you want to avoid or manage side effects from NPP, you need to understand how the steroid works. We’ve offered detailed information above. In most males, it is possible to avoid all side effects of this anabolic steroid. Here are the most common side effects associated with NPP:
Anadrol (commonly called by athletes “A50” or “A-bombs”) was initially developed as a compound to help people with anemia, and has since been used very successfully to aid people who are suffering from many other diseases where weight loss is a concern. Thus, it is clearly an effective agent for promoting weight gain, increasing appetite, gaining strength, and increasing Red Blood Cell count. And, as with most Anabolic/Androgenic Steroids (AAS), it has its downsides as well. Anadrol 50 will inhibit your body’s natural production of hormones (testosterone, etc ), will negatively affect your blood lipid profile, can cause water retention, is notorious for causing headaches, and is also highly liver toxic (in fact, it has the worst reputation for hepatoxicity out of all steroids). Paradoxically, although one the benefits touted by its original manufacturer (Syntex) is that it can be used to stimulate weight gain through increasing appetite, taking too much may actually inhibit your appetite!
I think, in order to gain a complete understanding of the Anadrol 50 effects on body, we need to take a look at its advantages contrasted with its disadvantages. Anadrol is a DHT-derived compound, and is 17-Alpha-Alkylated steroid, meaning that it has been altered at the 17th carbon position to survive oral ingestion. Most oral steroids are 17aa, and this helps them make it through your liver in a useful form. Sounds great, right? Lets 17alpha-alkylate everything! Well as you can imagine, there’s a down side.
This 17aa alteration, which makes it possible for Anadrol to survive its first pass through your liver, also makes it very taxing on your liver. How taxing is Anadrol and how much weight can you gain from its use? Well, there was a 30 week study done on Anadrol and, as you can expect, a reasonable amount of side effects were noted. The fact that Anadrol causes some side effects has really never been in debate. But how effective was the drug? Well, first it should be mentioned that this study was done on people with AIDS related wasting, and they actually gained weight (8+kg) while the control group lost weight, and had increased mortality rates. (1). I suppose, if you’re in a study because you have a wasting disease which is also a terminal illness, you don’t want to end up in the control group. Anyway, weight gain in this study peaked at 19-20 weeks, though, so the last 10 weeks weren’t very productive in this respect. Clearly, you wouldn’t want to run Anadrol 50 for 20 weeks, given its toxicity, but after that, any effect in terms of weight and strength gains would be negligible. So, with regards to sides from Anadrol, and the sheer fact that this study lasted so long (30 weeks), it should be apparent that they can be kept under control and the drug can be used safely. People are commonly told to limit their intake of Anadrol to 4 weeks or less I’m a bit less conservative and think you can easily run Anadrol for 6 weeks or more.
From personal experience, however, I can tell you that gains from Anadrol are quite dramatic for the first 3 weeks and then quickly level off. Unfortunately, I find that the side effects experienced from Anadrol (which include a headache, bloating, elevated blood pressure, and a general “unwell” feeling for me) remain for the entire duration of use. But I find as usual, side effects for this drug are pretty much half legend and half truth. Since Anadrol 50 is derived from DHT, it cant actually convert to estrogen (via the aromatase enzyme), and its not a progestin or a compound with progestenic activity so the estrogenic (?) side effects produced by it are of a very mysterious nature. It has been speculated that perhaps it can stimulate the estrogen receptor without actually being converted to estrogen and that’s about as plausible an explanation as Ive heard. However, things really get strange, when Oxymetholone has been used in studies to alter the female reproductive/menstrual cycle; in those cases, it has lowered plasma progesterone levels! (7)One would expect that an AI (aromatase inhibitor) wouldn’t be of much use with this drug, but many have found that Letrozole (which has, in some cases been shown to reduce estrogen in the body to an undetectable amount)(6) can greatly reduce or even eliminate many of the more noticeable side effects of Anadrol, such as the bloating.
As I’ve stated, however, the sides from this drug are certainly no joke, but are easily preventable, and controllable. One study even showed very few sides for subjects using up to 100mgs of Oxymetholone (2). In the original UnderGround Steroid Hand Book, Dan Duchaine states that he used it at doses up to 150mgs/day. Clearly, Anadrol’s hepatoxicity has been a bit exaggerated, in some circles. Be that as it may, my suggestion is still to limit Anadrol’s use to 6 weeks, at a maximum even if just to err on the side of caution. Of course, I have personally run this drug for much longer..
How should we use Anadrol? Id probably be willing to include Anadrol in a cycle including injectable steroids, but not other 17aa compounds. Id make any 6-week-run of this compound begin at the start of a cycle, as a form of “jumpstart” towards seeing gains quickly. The quick gains you will get from Anadrol (up to a pound per day for the first 2 weeks are not uncommon in Steroid.com members) are also just as quick to disappear upon cessation of use .unless you are simply using it as a kickstarter, while waiting for your other compounds to kick-in. Ill go out on a limb here and say that utilizing Anadrol as a “Jumpstart” is the most popular use of this drug for athletes and bodybuilders today. Ill also say that this drug is immensely popular with strength athletes who dont have to worry about weight classes (Field athletes and strongmen), and with powerlifters in the heavier weight brackets. Its also important to note that in one study by Schroder et. Al (2) Anadrol showed that it has the ability to lower serum SHBG (Sex Hormone Binding Globulin which binds to your free test and makes it no longer useful for anabolism, among other things) concentrations by 54.9 25.8 and 45 16.2 nmol/l in the 50- and 100-mg treatment groups. This means there will be more free test circulating around your body when you take this drug and clearly, this would produce some synergy when stacked with other steroids. Given the large amounts of weight and strength which can be gained in a relatively short time span on this drug, I’m sure this comes as no surprise to many.
Another important and often understated characteristic of this compound is that Oxymetholone doesn’t bind well to the androgen receptor (Relative Binding Affinity = too low to be determined) (3) which is the lowest Ive ever read about. Basically, what this tells me is that there are a lot of non-receptor mediated effects from this steroid, making it a very potent addition to ANY BULKING stack, because it wont be competing for the receptor sites with the other steroids you’re using. Its also, as you may have guessed a very poor choice for a cutting stack.
What is an Anadrol Cycle? How much should you use? Well, this is actually one of the most interesting facts about Anadrol 50. You see, most steroids produce what we call a “dose respondent curve” which is a fancy way of saying “the more you use, the more you gain.”
Anadrol is one of the few steroids where the dose respondent curve flattens out very quickly. When you take 50mgs of Anadrol, you’ll make some very good gains. When you take 100mgs of Anadrol, you’ll make even more gains. However, it has been found that 100mgs/day is as effective for weight gain as 150mgs/day but produces less side effects and was less toxic (4). I feel that the jump from 50mgs to 100mgs constitutes an acceptable rise in benefit vs. cost, but this is not the case as dosages get over 100mgs. Now, lets see how 50mgs and 100mgs of Oxymetholone actually effect strength, when compared with each other:
Relative (%) changes in strength are shown for the groups receiving placebo (filled bars), 50 mg/day oxymetholone (open bars), and 100 mg/day oxymetholone (gray bars). Nos. above bars represent relative change (%) from baseline to week 12 for the 1-repetition maximum tests of strength. Error bars represent 1 SE from the mean. * Significant difference from placebo, P < 0.05; significant difference from placebo by Wilcoxon test, P < 0.02. See text for additional statistical analyses.
As you can see, in this study, doubling the dose of Anadrol 50 nearly doubled the strength gains of the test subjects. Now, when we look at changes in body composition from Oxymetholone (chart below) we can see that although the guys taking the 100mgs (vs. the 50mgs group) had more fat lost and more Lean Body Mass gained, it wasn’t as dramatic as the differences in strength gains between the two groups:
Changes in body composition are shown for the groups receiving placebo (filled bars), 50 mg of oxymetholone per day (open bars), and 100 mg per day (gray bars). Numbers above the bars represent the mean absolute changes and the error bars are 1 SE. For total lean body mass (LBM) and total fat, differences among the 3 groups were significant (P < 0.0001, one-way ANOVA). * Significant differences from placebo, P 0.001.
Although I am usually not inclined to posit speculations on why a particular drug does or doesn’t do something, in this case I will. Im guessing that the higher doses of Anadrol cause enough appetite suppression (at least anecdotally) to make eating rather difficult. It can also increase insulin resistance and glucose intolerance (5). This has the effect of making macronutrient absorption more inefficient, and could also be a factor in reducing gains when the dosage goes over 100mgs/day. Unfortunately, Anadrol also has a reasonably profound effect on your body’s natural hormonal system, on par with most other oral steroids, but not as bad as most injectables, and its certainly not as harsh on your lipid profile as many anabolics are
(2). As an interesting side note, some of the medical literature on this compound suggests a dose of 1-5mgs per kg of bodyweight. Ill pause a second here for you to figure out how absurdly high of a dose that would translate to for the average bodybuilder!
Dianabol represents one of the most popular and one of the most important anabolic steroids of all time. Without question, this is the most popular oral steroid to ever hit the market and one of the most popular steroids in any form. While almost always found as an oral tablet, Dianabol can be found as an injectable solution, but the tablets represent the primary route of administration. Why is this steroid so important? In many ways it gave birth to the age of modern performance enhancement. It was not the first anabolic steroid used for that purpose, that would belong to testosterone, but Dianabol would open the door to a new wave of steroid use that has grown beyond what anyone expected.
Dianabol represents one of the only anabolic steroids that was developed for the sole purpose of performance enhancement. The compound did carry listed therapeutic uses at one time, but performance was the true reason this steroid was given life. Through the 1940’s and 50’s the Soviet Union had begun to dominate the Olympic games, and the use of testosterone by many of its athletes left the rest of the world lagging far behind. During this time, U.S. Olympic team Dr. John Ziegler would learn of the U.S.S.R.’s steroid use, and quickly would aid in ensuring his athletes would match up. In 1958, with the help of Dr. Ziegler, Ciba Pharmaceuticals would release the first batches of Methandrostenolone under the trade name Dianabol. The compound was designed in an effort to maintain the anabolic properties of testosterone with less androgenicity in a fast acting, powerful method. Seemingly overnight the steroid was a massive success, giving many U.S. athletes a distinct advantage over their Soviet rivals.
After its inception, Dianabol would quickly find its way into nearly every competitive sport imaginable. In conjunction with exogenous testosterone, this would birth an age of performance unlike the world had ever seen. The steroid would also rapidly become a staple in competitive bodybuilding where it has remained a favorite to this day. However, shortly after its release the U.S. FDA would begin to put a lot of pressure on Ciba in an effort to push the company to list true medical benefits of the steroid. The FDA would approve its use for the treatment osteoporosis in post-menopausal women as well as pituitary-deficient dwarfism, but the latter was withdrawn in the early 1980’s. Again the FDA would pressure Ciba for more information, but in 1983 under mounting pressure Ciba would discontinue the Dianabol tab. A few years later, the FDA would pull all Methandrostenolone brands from the shelf. Since that time Dianabol has not been legally manufactured in the United States, but is still manufactured heavily all over the world.
Methandrostenolone is a testosterone derived anabolic androgenic steroid. Officially, it is a structurally altered form of the primary male androgen testosterone. Dianabol is the testosterone hormone with an added double bond at the carbon one and two position. This slight alteration reduces the hormone’s androgenic nature. It also carries an added methyl group at the 17th carbon position that allows the hormone to survive oral ingestion, officially classifying Dianabol as a C17-alpha alkylated steroid. An important note, injectable Dianabol is also C17-alpha alkylated. The end result gives us an anabolic steroid with an androgenic rating of 40-60 with a much lower binding affinity to the androgen receptor compared to testosterone. However, it will also share a much weaker relationship for serum binding protein, which results in an extremely powerful anabolic steroid. If there’s any doubt, this is one extremely powerful anabolic steroid carrying a potent anabolic nature.
On a functional basis, Dianabol is one of the easier anabolic steroids to understand. This steroid will largely provide its anabolic benefits by enhancing protein synthesis, nitrogen retention and glycogenolysis. Protein synthesis represents the rate by which cells build proteins, the building blocks of muscle. Nitrogen retention, this is important as all muscle tissue is comprised of approximately 16% nitrogen. The more nitrogen we retain, the more anabolic we remain. Conversely, a nitrogen deficiency results in a catabolic or muscle wasting state. Then we’re left with glycogenolysis, which refers to the relationship and conversion between glycogen and glucose. Through enhanced glycogenolysis, we are able to make better use of our total carbohydrate consumption. While in many ways these traits are quite simple, they are strong enough to make Dianabol a remarkably powerful anabolic steroid.
Another important trait of Dianabol and perhaps one of the most important of all is the relationship it shares with other anabolic steroids. Dbol as it’s often called is not what we’d label as a base steroid. This is not an anabolic steroid we build a cycle around, but rather one we add to a well-planned stack. Dianabol has the ability to create unbelievable synergy when conjoined with other anabolic steroids. For example, you could supplement with 100mg of Trenbolone, Masteron or Equipoise per day (doses and steroids are simply being used as an example, not actual recommendations) and the results you’d receive from 50mg per day of Trenbolone, Masteron or Equipoise along side 50mg of Dianabol per day would be far more dramatic. You would have an identical amount of total milligrams of anabolic steroids with or without Dianabol, but the added Dianabol would provide greater enhancement.
The effects of Dianabol can be summed up as fast acting and dramatic. In fact, it is more than possible for the individual to gain as much as 20lbs of mass in only a few weeks of Dianabol use. Total dosing will play a role, as will total caloric consumption, but a 20lb gain is very realistic. This makes Dianabol a premier off-season bulking steroid, and that will be its most common purpose of use. During this phase of use, the individual should also expect his strength to increase significantly. Dbol is actually one of the best strength increasing steroids on the market and along with mass can produce this result rapidly.
The effects of Dianabol are also greatly appreciated by many athletes; however, it is not as common as it once was in athletic enhancement circles. Due to the possible rapid increases in mass, many athletes will opt for steroids like Anavar or Winstrol, but it generally depends on the purpose of use. Due to the rapid and pronounced increases in strength, which can translate into more power and speed, this can be a solid athletic enhancer. The individual should also experience a level of enhanced recovery and endurance. When it comes to the weight gain, it’s important to remember that this will largely revolve around total caloric intake. While the steroid can promote enormous amounts of mass, you have to feed the body enough calories to reach this end. We wouldn’t call this the best athletic enhancing steroid due to other options, but if strength is the only true concern it could be a decent option.
Then we’re left with the cutting cycle, and you will not find Dianabol in such plans too often. Some competitive bodybuilders will use it early on in a cutting phase in order to maintain fullness, and it will provide lean tissue protection; however, there are better options. One problem with cutting cycle use can be the level of water retention this steroid can provide, which is normally the last thing you want when cutting. Such retention can be controlled, and the ability for this steroid to maintain strength can be appreciated, but there are better options.
There are several possible side effects of Dianabol use. This is not the most dangerous anabolic steroid of all time, but it can carry a host of potential problems. A healthy adult male can manage the side effects of Dianabol, but you must understand them and how to combat them to pull this off. In order to achieve successful supplementation, we have broken down the possible side effects of Dianabol into their related categories along with all you need to know