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Nolvadex (Tamoxifen) is one of the oldest and most popular selective estrogen receptor modulators (SERM’s) in the world. Tamoxifen Citrate was developed in 1961 by Imperial Chemical Industries (ICI) under the trade name Nolvadex. Later, AstraZeneca purchased ICI. Tamoxifen can be used to treat a large amount of dysfunctions, that’s why it was included in the World Health Organization’s list of essential medications. Nolvadex is also widely used by androgenic anabolic steroid users.
The drug was created to treat hormone-responsive breast cancer, then it turned out that it also can be used to prevent breast cancer. Nolvadex also can be used to treat women’s infertility, however studies have shown less effective results than from Clomid (Clomiphene).
In bodybuilding Tamoxifen can be used for two goals. The first option is as an anti-estrogen during an androgenic anabolic steroid cycle in order to prevent estrogen related side effects such as gynecomastia, bloating, high blood pressure, etc. However, similar to the case with Clomid (Clomiphene), I believe that there are more effective drugs such as Anastrozole or Proviron to prevent estrogenic side effects. The second most beneficial option is going through Post Cycle Therapy (PCT) in order to boost the Luteinizing Hormone and testosterone level.
Tamoxifen is a selective estrogen receptor modulator (SERM) with both estrogen agonist and antagonist properties. For the androgenic anabolic steroid users, one of the desired effects is in the prevention of gynecomastia. Tamoxifen also reduces other estrogenic side effects like water retention and blood pressure but not significantly. That’s why I recommend using other drugs to reduce the estradiol level like Anastrozole and Proviron, however Nolvadex can be used for a weak cycle and it has less side effects. Additionally, Nolvadex has a positive impact on cholesterol levels.
The most valuable effect of Nolvadex is boosting the testosterone level for Post Cycle Therapy (PCT). During the cycle your body stops producing its own testosterone because it realizes there are too many hormones. The rate of suppression depends on the steroid cycle, the more advanced the cycle the worse your natural testosterone level will be. Once the cycle is done the natural testosterone production will start slowly recovering again. However, after you’ve finished the cycle your natural testosterone level will be extremely low and it will take time to recover naturally.
No one, especially bodybuilders, would want to stay in a low testosterone condition because it can lead to high body fat, loss of muscles, etc.
Most athletes have a post cycle therapy plan in order to recover their testosterone level faster. Nolvadex one of the medications that is very effective in helping to recover the testosterone level. Nolvadex stimulates the higher release of both luteinizing hormone and follicle stimulating hormone. When the body indicates a rise in luteinizing hormone (LH) it starts producing testosterone. That helps in maintaining a higher testosterone level until your natural testosterone has completely recovered.
Dosages
In bodybuilding, for the purposes of post cycle therapy, your dosage should depend on the cycle. If the cycle was short (6-8 weeks) with one steroid or small steroids dosages you should use 20 milligrams for 14 days. If your cycle was advanced, the dosage of Nolvadex can be up to 50 milligrams per day for 6 weeks with gradually decreasing dosages. Also you can use a combination Nolvadex (Tamoxifen) with Clomid (Clomiphene) after advanced cycles.
The same as with Clomid it’s very important to start using Tamoxifen timely. After oral only cycles like Turinabol, Winstrol and Dianabol you should start using Nolvadex a day after your cycle is completed. If a cycle contains short duration esters, begin using Nolvadex 3 days after the cycle. If a cycle includes long lasting esters you should wait 14 days before using Nolvadex.
For the purpose of decreasing estrogenic side effects during an androgenic anabolic steroid cycle, the optimal dosage is from 10 to 20 milligrams per day. If this dosage does not help to protect from gynecomastia you should consider using aromatase inhibitors such as Anastrozole or Proviron.
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Anastrozole
Arimidex, known by its chemical name Anastrozole is an aromatase inhibitor. Why should that concern bodybuilders? The aromatase enzyme is responsible for the production of estrogens in the body. By inhibiting it, Arimidex lowers estrogen levels in the body [R]
Here’s why that is important. Many bodybuilders use anabolic steroids to build muscle, lose fat and improve athletic performance. What most anabolic steroid users may not know is that they increase estrogen levels in the body, exposing your body to serious side effects.
That is where Arimidex enters the picture. By inhibiting the aromatase enzyme and slowing the production of estrogen, this drug helps prevent gynecomastia. That’s because estrogen is to the breast tissue as gasoline is to your car. The latter needs the former to function.
Keep in mind that the benefits of Arimidex aren’t limited to preventing gynecomastia. This drug may also prevent infertility, erectile dysfunction, and depression in the male population. All of these are the side effects of the anabolic steroid cycles. [R]
If you’re in a hurry and want to have a quick overview of the benefits and side effects of Arimidex PCT, this section has you sorted.
Remember that most of these side effects tend to be mild, as long as you stick to the recommended dosage (more on this below).Also, if you’re looking for an alternative to anabolic steroids, one that could boost your body’s natural testosterone production, check out our guide on selective androgen receptor modulators.Bodybuilders use Arimidex as a Post Cycle Therapy because it inhibits the production of estrogen. This hormone has many vital functions in the body, both male and female. But its elevated levels in men’s system lead to gynecomastia, or breast growth. That’s what Arimidex helps prevent.Arimidex does that by reducing estrogen production in the body. This, in turn, lowers the supply of the female hormone to the breast tissue. With the incoming supply of fuel (estrogen) that it needs to grow depleted, the ability of the breast tissue to expand nosedives.
One of the major benefits of Arimidex is that it might help or treat gynecomastia. However, its utility doesn’t end there. This aromatase inhibitor has also shown promise in treating erectile dysfunction, infertility and depression among the male population.Here are the major benefits you may expect from Arimidex:
According to an estimate, gynecomastia is one of the most common male breast disorders. Up to 70% of boys and men develop ‘man boobs’ in early to mid-puberty. Most of them develop gynecomastia due to regular hormone changes. Some, however, get it due to anabolic steroids use. [R]
Clenbutero Hydrochloride is a powerful bronchodilator that is used to treat breathing disorders like asthma. While it’s been extremely successful in such treatment plans it has never been approved by the U.S. FDA. It is, however, approved and used in most other countries around the world. Some speculate the only reason Clenbuterol has never been approved by the U.S. FDA is due to there being no need. There are several other related medications, very closely related that are already approved for U.S. use.
Beyond treating breathing disorders, Clenbuterol is commonly used as a thermogenic. In fact, you will more than likely find more Clenbuterol use in fat loss plans than anywhere else. It is a very common fat burning tool used by many anabolic steroid users. It is a long standing favorite among competitive bodybuilders and other physique athletes during contest preparation. However, it is also used by non-steroid users for its fat loss properties. You do not have to use anabolic steroids to use this compound for fat loss. We only mention that because this has for some reason become a confusing point for some.
Clenbuterol Hydrochloride is a sympathomimetic that works on the sympathomimetic nervous system. There are several receptors in the body a sympathomimetic can act on. In the case of Clenbuterol, the beta-2 receptor is the area of interest and action. Clen, as it’s commonly known, actively stimulates the beta-2 receptor. Through such stimulation, this actively reverses airway obstructions and provides improved breathing for those who need it. This same stimulation can also be used to enhance the metabolic rate of the individual. Clenbuterol does not actively burn fat by attacking fat cells, but rather stimulates the metabolism by increasing the body’s temperature. This occurs due to the beta-2 stimulation stimulating the mitochondria of the cells to produce and release more heat. In turn, this heats up the body’s temperature (slightly), enhances the metabolism and causes the individual to burn body fat at a greater rate. In reality, the functions and traits of Clenbuterol are very simple and very straightforward.
Clenbuterol has also been noted for having a strong anabolic effect; however, things are not quite like they appear. Due to the potential anabolic effect, this has caused many to use the compound in hopes of gaining lean tissue. Commonly, many steroid users have used it as an anabolic protective agent during their post cycle therapy (PCT). There is, however, a problem with this type of use; it doesn’t work. Studies have shown that Clenbuterol has the ability to promote anabolic activity in animals. There have been several studies that have shown the anabolic activity of rats to increase when Clen is administered. However, there is no data that supports such anabolic activity provided when used by human beings. In fact, it has generally been proven useless in this regard as it pertains to human beings. When it comes to human Clenbuterol use, use as a bronchodilator and thermogenic are the only suitable purposes.
The effects of Clenbuterol on the asthmatic patient are as straightforward as can be. Use of the bronchodilator opens up the airways and enables the individual to breath. There are other breathing disorders that can benefit from Clenbuterol use, but asthma appears to be primary, and it is often a welcomed medication to those who suffer. This same improved breathing could also prove useful to some athletes, especially those who can benefit from enhanced cardiovascular endurance. However, we’re not talking about a strong, notable improvement and there are truly other methods that are far more suited for increasing cardiovascular endurance.
As a thermogenic, the effects of Clenbuterol are again very simple. As the body temperature increases, which again is due to the beta-2 stimulation, the individual is now able to burn calories at an enhanced rate. Body temperature goes up, the metabolism is enhanced, fat cells are stimulated due to the increase in temperature due to the now enhanced metabolism, the breakdown of triglycerides is now enhanced and fat loss occurs. It’s hard to get any simpler than that.
While Clenbuterol is a powerful fat loss agent, it is not magical and will not make a fat physique lean on its own. You still have to diet in order to lose body fat, and if you don’t, no fat loss will occur. In fact, even if you’re using Clenbuterol you will still find you need to diet just as hard as you would without it if you are going to lose body fat. This raises an important question; why use Clen? The idea behind Clenbuterol use as a thermogenic in simple terms it to take what you’re already doing right and to simply do it a little better. It’s not going to melt fat off your frame, but it can rev up the metabolism and help you burn fat at a more effective and efficient rate. If you are obese or at least significantly overweight, your best bet is to forgo Clenbuterol use until you are at least a little leaner. The best time to use Clen is once you’re already fairly lean in an effort to help you rid that last little body fat that often hangs on for dear life. When we dive into the side effects of Clenbuterol, we will find Clen can and should only be used for a set period of time, and it only makes sense to use it when it will be the most beneficial.
Due to Clenbuterol being best served for final touches in a fat loss plan, this is why you’ll see it in many physique based plans such as bodybuilding, figure, fitness or other related endeavors. It’s commonly used the last 8-10 weeks leading up to a competition, sometimes a little longer, but regardless of the specific time frame the individual is normally already fairly lean. For the average gym rat, one who doesn’t compete but is looking to lean out, we can make some slight exceptions. We’re not saying you have to be contest ready lean in order for their to be a benefit. If you’re already in fairly good shape and looking to lean out a little more, absolutely, Clenbuterol can prove useful. But if you truly have a lot of body fat to lose, you’ll be best served by waiting until your body fat is a little more under control.
There are several possible side effects to Clenbuterol use, and the primary will surround its stimulating nature. No surprise, after all, Clen is a stimulant. The side effects of Clenbuterol can be very strong and often very annoying to say the least, and they will generally affect most people in one way or another. The most common side effects surround a jittery or wired feeling, shaky hands and increased sweating. Most all who use Clen will experience such effects to a degree, but they will commonly be very pronounced during the early stages of use. As the individual becomes accustomed to the stimulant, such related effects should begin to subside, but they will be so strong in some people that some will not be able to use it.
When using Clenbuterol, many often inaccurately assume that when the stimulating effects of Clen began to fade that the thermogenic effects are no longer working. Most will find that the stimulating effects will greatly subside after a week or so of use, but assuming the fat burning properties have vanished due to this lessened stimulation is highly inaccurate. The same dose of Clenbuterol Hydrochloride can actually keep the metabolism revved for as much as five weeks. Granted, by the fifth week mark it will be minimal as the body does most certainly adapt. Due to the body’s ability to adapt, necessarily adjustments must be made to use. We will go over adjustments, dosing plans and total plans of use in the Clenbuterol in the administration section.
The aforementioned side effects of Clenbuterol are the most common, but there are other possible effects of note. As with many stimulating substances, some will experience headaches as well as possible nausea. One of the more bothersome possible side effects of Clenbuterol Hydrochloride will be muscle cramps. Cramps are not exceedingly common, but they will affect many people. Athletes are often at the greatest risk due to the hard and often intense training they are already undertaking. Staying well hydrated is often enough to avoid or remedy this problem, but supplementing with taurine can also help. Clen has been shown to deplete taurine, so supplementation may be necessary for some. Some may also have issues with insomnia; in fact, some may find sleep becomes extremely difficult. Again, this is very common with many stimulating substances, but with Clen it can, for some, be impossible to avoid. Clen has an active half-life that stretches to the 34 hour mark, and that can make sleep impossible for some people. Many will, however, find if they take their Clen first thing in the morning they will not have any issues with sleep, but due to the long half-life some will find insomnia occurs regardless of when they take it.
The use of Clenbuterol Hydrochloride also carries with it possible side effects that can be severe; in fact, dangerous would be a more accurate description. Such effects are most commonly associated with abuse through high doses and far beyond recommended extended periods of use. The severe side effects of Clenbuterol include high blood pressure, irregular heartbeat, trembling and even panic. Some studies have also shown that Clenbuterol abuse can also lead to cardiac hypertrophy, which could potentially lead to death. It is very possible to use this compound without such effects, but as with so many things in life it will require responsible use and a thorough understanding of Clen.
In a therapeutic setting, Clenbuterol doses will most commonly be 20mcg per day, with some requiring 40mcg per day. It is possible for some to need even more, but it is rare and generally only for a short period of time. This should, in most all cases, be enough Clen to correct related breathing issues, if not, alternative treatments may be needed.
In a performance setting as a thermogenic, Clenbuterol doses will start low and generally increase overtime due to a down regulation of the beta-receptor. Most men will find starting at 40mcg per day to be perfect. Many women may also be fine with this starting dose, but many will be far more comfortable with a starting dose of 20mcg per day. As the body adapts, the dose will need to increase in order to maintain the full fat loss benefits. There are several schools of thought on the best way to use Clen in a fat burning setting, but there are only three that really make any sense. All three will work very well, but you may need to try all three at separate times to find which one works best for you.
One of the most common methods of Clenbuterol use for fat loss purposes is two weeks on followed by two weeks off. This type of use will normally continue until the end goal is reached. The individual will start with the initial dose and increase it by 20mcg every few days until he has reached the maximum desired or needed dose. The individual will then hold at this dose the final days of the two week period and then discontinue all Clenbuterol use for two weeks. At the end of the two weeks with no Clen, the individual will begin the process again.
The two week rotation schedule is very effective, but there is also a problem. During the off periods you have no Clen in your system, and as a result, a two week period with a decreased metabolic rate. This does not mean you won’t be burning fat during the off week periods, as long as you’re dieting you should still lose fat, but you are giving up the enhancement.
Due to the body’s ability to adapt to Clenbuterol, continuous use is very hard for some to get their head around. When we consider that the stimulating effects of a noticeable nature began to wane first, the idea of continuous use for some doesn’t make any sense, but we assure you this method of use can work very well. Remember, the same dose of Clen can keep the metabolism revved for up to 5 weeks.
With this type of use, the individual will begin with the starting dose of 20-40mcg per day and hold at that dose for 2-3 weeks. At the end of the 2-3 week period, the individual will increase the dose by 20mcg and hold at that dose for another 2-3 weeks. From here, the individual will increase the dose 20mcg every 2-3 weeks as needed until the diet or total Clen use comes to an end. This type of use will keep your metabolism revved the entire time. It may not experience as great of an increase as would with a massive or very frequent increasing in dose schedule, but it will be a steady and continuous enhancement. There will be no period in the diet during Clenbuterol use that the individual doesn’t enjoy the metabolic enhancement.
The final preferred method of Clenbuterol use falls in-between our other two discussed methods. This type of use will last for 4-6 weeks and can be an excellent way to use it for the individual who is only using it the last few weeks leading up to competition. The individual will start with 40mcg per day and increase periodically until he reaches the maximum desired or needed dose and will hold at the maximum dose the final 7-14 days of the plan. The increases in dosing will not be as dramatic as the two week rotation schedule but stronger than the continuous plan. At this stage, if more Clen is still needed, the individual will need to wait 4-6 weeks before beginning a new phase. This makes this type of use best for those who only need a short period of metabolic enhancement.
Regardless of the type of schedule you use, the maximum Clenbuterol dose will normally be 120mcg per day. Some may find 140mcg per day to be acceptable, especially some men, but no one should for any reason surpass the 140mcg per day mark if they are going to avoid cardiac damage. Regardless of the total dosing or plan of use you use, Clenbuterol use should be kept at no more than 16 weeks of total use. 16 weeks of total use per year should be your guide. For the individual competing in more than one show per year at different stages of the year, we can make exceptions. However, this individual should try to keep the total use as close to a 16 week total every 12 months as possible for safety reasons
Cialis (tadalafil) is the only medication in its class that treats both erectile dysfunction and enlarged prostate symptoms. You can also take it on a regular basis, which can allow for more spontaneity.
Cialis (tadalafil) is a phosphodiesterase-5 enzyme (PDE-5) inhibitor, meaning it blocks PDE-5. This relaxes certain muscles and blood vessels, which increases blood flow to the penis to help with an erection. Cialis (tadalafil) also treats enlarged prostate symptoms.
How long does it take for Cialis (tadalafil) to work?
Cialis (tadalafil) will kick in about 30 minutes after taking it, though it may take longer for some people. On average, it can take up to 2 hours for full effect.
Pros and cons of Cialis (tadalafil)
A first-choice medication for treating erectile dysfunction
Can be taken either as needed, or on a regular basis for those who need it more regularly — this means you can be more spontaneous about the timing of sex.
Lasts longer than Viagra (sildenafil)
Can’t be taken if you’ve had a heart attack in the past 3 months, or a stroke or heart failure in the past 6 months
Can’t be used if you’ve recently taken nitrates like Isordil, Imdur, or nitroglycerin (Nitro-BID, Nitro-Dur, Nitrostat)
Could have more side effects for people who are 65 or older — use this medication with care
Cialis (tadalafil) can be dosed in two ways: (1) taken on a daily basis, or (2) only when you need it. If you’re taking Cialis (tadalafil) on a regular basis, take it at the same time every day.
If you get muscle or back pain with Cialis (tadalafil), it should get better in about 2 days. Talk to your doctor if your symptoms don’t improve.
If you have an erection for more than 4 hours, go to the emergency department (ED) or call your doctor immediately as this can lead to damage to the penis.
Cialis (tadalafil) does not stop the spread of sexually transmitted diseases (STDs) like herpes or HIV. Be sure to practice safe sex.
Anadrol (commonly called by athletes “A50” or “A-bombs”) was initially developed as a compound to help people with anemia, and has since been used very successfully to aid people who are suffering from many other diseases where weight loss is a concern. Thus, it is clearly an effective agent for promoting weight gain, increasing appetite, gaining strength, and increasing Red Blood Cell count. And, as with most Anabolic/Androgenic Steroids (AAS), it has its downsides as well. Anadrol 50 will inhibit your body’s natural production of hormones (testosterone, etc ), will negatively affect your blood lipid profile, can cause water retention, is notorious for causing headaches, and is also highly liver toxic (in fact, it has the worst reputation for hepatoxicity out of all steroids). Paradoxically, although one the benefits touted by its original manufacturer (Syntex) is that it can be used to stimulate weight gain through increasing appetite, taking too much may actually inhibit your appetite!
I think, in order to gain a complete understanding of the Anadrol 50 effects on body, we need to take a look at its advantages contrasted with its disadvantages. Anadrol is a DHT-derived compound, and is 17-Alpha-Alkylated steroid, meaning that it has been altered at the 17th carbon position to survive oral ingestion. Most oral steroids are 17aa, and this helps them make it through your liver in a useful form. Sounds great, right? Lets 17alpha-alkylate everything! Well as you can imagine, there’s a down side.
This 17aa alteration, which makes it possible for Anadrol to survive its first pass through your liver, also makes it very taxing on your liver. How taxing is Anadrol and how much weight can you gain from its use? Well, there was a 30 week study done on Anadrol and, as you can expect, a reasonable amount of side effects were noted. The fact that Anadrol causes some side effects has really never been in debate. But how effective was the drug? Well, first it should be mentioned that this study was done on people with AIDS related wasting, and they actually gained weight (8+kg) while the control group lost weight, and had increased mortality rates. (1). I suppose, if you’re in a study because you have a wasting disease which is also a terminal illness, you don’t want to end up in the control group. Anyway, weight gain in this study peaked at 19-20 weeks, though, so the last 10 weeks weren’t very productive in this respect. Clearly, you wouldn’t want to run Anadrol 50 for 20 weeks, given its toxicity, but after that, any effect in terms of weight and strength gains would be negligible. So, with regards to sides from Anadrol, and the sheer fact that this study lasted so long (30 weeks), it should be apparent that they can be kept under control and the drug can be used safely. People are commonly told to limit their intake of Anadrol to 4 weeks or less I’m a bit less conservative and think you can easily run Anadrol for 6 weeks or more.
From personal experience, however, I can tell you that gains from Anadrol are quite dramatic for the first 3 weeks and then quickly level off. Unfortunately, I find that the side effects experienced from Anadrol (which include a headache, bloating, elevated blood pressure, and a general “unwell” feeling for me) remain for the entire duration of use. But I find as usual, side effects for this drug are pretty much half legend and half truth. Since Anadrol 50 is derived from DHT, it cant actually convert to estrogen (via the aromatase enzyme), and its not a progestin or a compound with progestenic activity so the estrogenic (?) side effects produced by it are of a very mysterious nature. It has been speculated that perhaps it can stimulate the estrogen receptor without actually being converted to estrogen and that’s about as plausible an explanation as Ive heard. However, things really get strange, when Oxymetholone has been used in studies to alter the female reproductive/menstrual cycle; in those cases, it has lowered plasma progesterone levels! (7)One would expect that an AI (aromatase inhibitor) wouldn’t be of much use with this drug, but many have found that Letrozole (which has, in some cases been shown to reduce estrogen in the body to an undetectable amount)(6) can greatly reduce or even eliminate many of the more noticeable side effects of Anadrol, such as the bloating.
As I’ve stated, however, the sides from this drug are certainly no joke, but are easily preventable, and controllable. One study even showed very few sides for subjects using up to 100mgs of Oxymetholone (2). In the original UnderGround Steroid Hand Book, Dan Duchaine states that he used it at doses up to 150mgs/day. Clearly, Anadrol’s hepatoxicity has been a bit exaggerated, in some circles. Be that as it may, my suggestion is still to limit Anadrol’s use to 6 weeks, at a maximum even if just to err on the side of caution. Of course, I have personally run this drug for much longer..
How should we use Anadrol? Id probably be willing to include Anadrol in a cycle including injectable steroids, but not other 17aa compounds. Id make any 6-week-run of this compound begin at the start of a cycle, as a form of “jumpstart” towards seeing gains quickly. The quick gains you will get from Anadrol (up to a pound per day for the first 2 weeks are not uncommon in Steroid.com members) are also just as quick to disappear upon cessation of use .unless you are simply using it as a kickstarter, while waiting for your other compounds to kick-in. Ill go out on a limb here and say that utilizing Anadrol as a “Jumpstart” is the most popular use of this drug for athletes and bodybuilders today. Ill also say that this drug is immensely popular with strength athletes who dont have to worry about weight classes (Field athletes and strongmen), and with powerlifters in the heavier weight brackets. Its also important to note that in one study by Schroder et. Al (2) Anadrol showed that it has the ability to lower serum SHBG (Sex Hormone Binding Globulin which binds to your free test and makes it no longer useful for anabolism, among other things) concentrations by 54.9 25.8 and 45 16.2 nmol/l in the 50- and 100-mg treatment groups. This means there will be more free test circulating around your body when you take this drug and clearly, this would produce some synergy when stacked with other steroids. Given the large amounts of weight and strength which can be gained in a relatively short time span on this drug, I’m sure this comes as no surprise to many.
Another important and often understated characteristic of this compound is that Oxymetholone doesn’t bind well to the androgen receptor (Relative Binding Affinity = too low to be determined) (3) which is the lowest Ive ever read about. Basically, what this tells me is that there are a lot of non-receptor mediated effects from this steroid, making it a very potent addition to ANY BULKING stack, because it wont be competing for the receptor sites with the other steroids you’re using. Its also, as you may have guessed a very poor choice for a cutting stack.
What is an Anadrol Cycle? How much should you use? Well, this is actually one of the most interesting facts about Anadrol 50. You see, most steroids produce what we call a “dose respondent curve” which is a fancy way of saying “the more you use, the more you gain.”
Anadrol is one of the few steroids where the dose respondent curve flattens out very quickly. When you take 50mgs of Anadrol, you’ll make some very good gains. When you take 100mgs of Anadrol, you’ll make even more gains. However, it has been found that 100mgs/day is as effective for weight gain as 150mgs/day but produces less side effects and was less toxic (4). I feel that the jump from 50mgs to 100mgs constitutes an acceptable rise in benefit vs. cost, but this is not the case as dosages get over 100mgs. Now, lets see how 50mgs and 100mgs of Oxymetholone actually effect strength, when compared with each other:
Relative (%) changes in strength are shown for the groups receiving placebo (filled bars), 50 mg/day oxymetholone (open bars), and 100 mg/day oxymetholone (gray bars). Nos. above bars represent relative change (%) from baseline to week 12 for the 1-repetition maximum tests of strength. Error bars represent 1 SE from the mean. * Significant difference from placebo, P < 0.05; significant difference from placebo by Wilcoxon test, P < 0.02. See text for additional statistical analyses.
As you can see, in this study, doubling the dose of Anadrol 50 nearly doubled the strength gains of the test subjects. Now, when we look at changes in body composition from Oxymetholone (chart below) we can see that although the guys taking the 100mgs (vs. the 50mgs group) had more fat lost and more Lean Body Mass gained, it wasn’t as dramatic as the differences in strength gains between the two groups:
Changes in body composition are shown for the groups receiving placebo (filled bars), 50 mg of oxymetholone per day (open bars), and 100 mg per day (gray bars). Numbers above the bars represent the mean absolute changes and the error bars are 1 SE. For total lean body mass (LBM) and total fat, differences among the 3 groups were significant (P < 0.0001, one-way ANOVA). * Significant differences from placebo, P 0.001.
Although I am usually not inclined to posit speculations on why a particular drug does or doesn’t do something, in this case I will. Im guessing that the higher doses of Anadrol cause enough appetite suppression (at least anecdotally) to make eating rather difficult. It can also increase insulin resistance and glucose intolerance (5). This has the effect of making macronutrient absorption more inefficient, and could also be a factor in reducing gains when the dosage goes over 100mgs/day. Unfortunately, Anadrol also has a reasonably profound effect on your body’s natural hormonal system, on par with most other oral steroids, but not as bad as most injectables, and its certainly not as harsh on your lipid profile as many anabolics are
(2). As an interesting side note, some of the medical literature on this compound suggests a dose of 1-5mgs per kg of bodyweight. Ill pause a second here for you to figure out how absurdly high of a dose that would translate to for the average bodybuilder!